Article
Tumoral expression of drug and xenobiotic metabolizing enzymes in breast cancer patients of different ethnicities with implications to personalized medicine.
Scientific reports - 6 Jul 2017
Li Yan, Steppi Albert, Zhou Yidong, Mao Feng, Miller Philip Craig, He Max M, Zhao Tingting, Sun Qiang, Zhang Jinfeng
Abstract excerpt
Drug and xenobiotic metabolizing enzymes (DXME) play important roles in drug responses and carcinogenesis. Recent studies have found that expression of DXME in cancer cells significantly affects drug clearance and the onset of drug resistance. In this study we compared the expression of DXME in breast tumor tissue samples from patients representing three ethnic groups: Caucasian Americans (CA), African Americans...
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