Article

Deciphering drug response and phenotypic heterogeneity of cancer cells using gene ensembles of regulatory units defined by chromatin domains

2023-01-18

Abstract excerpt

The effect of co-localization of genes in the topologically associated domains (TADs) and their activity as a regulatory unit in cancer samples and cells, together with drug-response, needs comprehensive analysis. Here, we analyzed the activity of TADs using cancer-cell transcriptomes along with chromatin-interaction and epigenome profiles to understand their relationship with drug-response. Our analysis of 819 ca...

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Literature Corpus work: 657670ff-5eeb-5b45-837c-316a1b3c2645
DOI: 10.1101/2023.01.15.524115

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