Article
Mutational landscape of risk variants in comorbid depression and obesity: a next-generation sequencing approach.
Molecular psychiatry - 1 Nov 2024
Pérez-Gutiérrez Ana M, Carmona Rosario, Loucera Carlos, Cervilla Jorge A, Gutiérrez Blanca, Molina Esther, Lopez-Lopez Daniel, Pérez-Florido Javier, Zarza-Rebollo Juan Antonio, López-Isac Elena, Dopazo Joaquín, Martínez-González Luis Javier, Rivera Margarita
Abstract excerpt
Major depression (MD) and obesity are complex genetic disorders that are frequently comorbid. However, the study of both diseases concurrently remains poorly addressed and therefore the underlying genetic mechanisms involved in this comorbidity remain largely unknown. Here we examine the contribution of common and rare variants to this comorbidity through a next-generation sequencing (NGS) approach. Specific...
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