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Article

Sex differences in shared genetic determinants between severe mental disorders and metabolic traits.

Psychiatry research - 1 Dec 2024

Pisanu Claudia, Congiu Donatella, Meloni Anna, Paribello Pasquale, Severino Giovanni, Ardau Raffaella, Chillotti Caterina, Als Thomas D, Børglum Anders D, Del Zompo Maria, Manchia Mirko, Squassina Alessio

Abstract excerpt

High rates of metabolic risk factors contribute to premature mortality in patients with severe mental disorders, but the molecular underpinnings of this association are largely unknown. We performed the first analysis on shared genetic factors between severe mental disorders and metabolic traits considering the effect of sex. We applied an integrated analytical pipeline on the largest sex-stratified genome-wide...

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Identifiers

PMID: 39299147
DOI: 10.1016/j.psychres.2024.116195

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