Article
G-Quadruplex Forming DNA Sequence Context Is Enriched around Points of Somatic Mutations in a Subset of Multiple Myeloma Patients.
International journal of molecular sciences - 12 May 2024
Zhuk Anna S, Stepchenkova Elena I, Zotova Irina V, Belopolskaya Olesya B, Pavlov Youri I, Kostroma Ivan I, Gritsaev Sergey V, Aksenova Anna Y
Abstract excerpt
Multiple myeloma (MM) is the second most common hematological malignancy, which remains incurable despite recent advances in treatment strategies. Like other forms of cancer, MM is characterized by genomic instability, caused by defects in DNA repair. Along with mutations in DNA repair genes and genotoxic drugs used to treat MM, non-canonical secondary DNA structures (four-stranded G-quadruplex structures) can...
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