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Article

Genomic instability in multiple myeloma: mechanisms and therapeutic implications

1 Jun 2013

Abstract excerpt

INTRODUCTION: Clonal plasma cells in multiple myeloma (MM) are typified by their nearly universal aneuploidy and the presence of recurrent chromosomal aberrations reflecting their chromosomal instability. Multiple myeloma is also recognized to be heterogeneous with distinct molecular subgroups. Deep genome sequencing studies have recently revealed an even wider heterogeneity and genomic instability with the...

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Chromosomal and Genetic Variations
Microtubule and mitosis dynamics
Multiple Myeloma Research and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23782016
DOI: 10.1517/14712598.2013.814637

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