Germline Risk Contribution to Genomic Instability in Multiple Myeloma

Abstract excerpt

Genomic instability, a well-established hallmark of human cancer, is also a driving force in the natural history of multiple myeloma – a difficult to treat and in most cases fatal neoplasm of immunoglobulin producing plasma cells that reside in the hematopoietic bone marrow. Long recognized manifestations of genomic instability in myeloma at the cytogenetic level include abnormal chromosome numbers (aneuploidy)...

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