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Article

Dysregulated APOBEC3G causes DNA damage and promotes genomic instability in multiple myeloma.

Blood cancer journal - 8 Oct 2021

Talluri Srikanth, Samur Mehmet K, Buon Leutz, Kumar Subodh, Potluri Lakshmi B, Shi Jialan, Prabhala Rao H, Shammas Masood A, Munshi Nikhil C

Abstract excerpt

Multiple myeloma (MM) is a heterogeneous disease characterized by significant genomic instability. Recently, a causal role for the AID/APOBEC deaminases in inducing somatic mutations in myeloma has been reported. We have identified APOBEC/AID as a prominent mutational signature at diagnosis with further increase at relapse in MM. In this study, we identified upregulation of several members of APOBEC3 family (A3A,...

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Identifiers

PMID: 34625538
DOI: 10.1038/s41408-021-00554-9
PMCID: PMC8501035

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