Article
Interaction between miR-142-3p and BDNF Val/Met Polymorphism Regulates Multiple Sclerosis Severity.
International journal of molecular sciences - 11 May 2024
Dolcetti Ettore, Musella Alessandra, Balletta Sara, Gilio Luana, Bruno Antonio, Stampanoni Bassi Mario, Lauritano Gianluca, Buttari Fabio, Fresegna Diego, Tartacca Alice, Mariani Fabrizio, Palmerio Federica, Rovella Valentina, Ferese Rosangela, Gambardella Stefano, Giardina Emiliano, Finardi Annamaria, Furlan Roberto, Mandolesi Georgia, Centonze Diego, De Vito Francesca
Abstract excerpt
MiR-142-3p has recently emerged as key factor in tailoring personalized treatments for multiple sclerosis (MS), a chronic autoimmune demyelinating disease of the central nervous system (CNS) with heterogeneous pathophysiology and an unpredictable course. With its involvement in a detrimental regulatory axis with interleukin-1beta (IL1β), miR-142-3p orchestrates excitotoxic synaptic alterations that significantly...
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