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Article

Brain Atrophy Associated With Risk Variant rs10191329 Extends Beyond Multiple Sclerosis.

Annals of neurology - 1 Apr 2026

Corsten Cato E A, Marques Ana M, Vinke Elisabeth J, de Mol C Louk, Neuteboom Rinze F, Ikram M Kamran, Ghanbari Mohsen, Wolters Frank J, Wokke Beatrijs, Vernooij Meike W, Smolders Joost

Abstract excerpt

The risk allele rs10191329*A is associated with disease severity and brain atrophy in people with multiple sclerosis (MS). We investigated the association of rs10191329 with age-related brain atrophy in a population-based cohort using 10,308 magnetic resonance imaging (MRI) scans of 4,815 participants aged ≥ 45 years without MS in cross-sectional and longitudinal analyses. We observed associations between the...

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PMID: 41489020
DOI: 10.1002/ana.78148
PMCID: PMC13011790

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