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The BDNF Val66Met Polymorphism (rs6265) Modulates Inflammation and Neurodegeneration in the Early Phases of Multiple Sclerosis.

Genes - 10 Feb 2022

Dolcetti Ettore, Bruno Antonio, Azzolini Federica, Gilio Luana, Moscatelli Alessandro, De Vito Francesca, Pavone Luigi, Iezzi Ennio, Gambardella Stefano, Giardina Emiliano, Ferese Rosangela, Buttari Fabio, Rizzo Francesca Romana, Furlan Roberto, Finardi Annamaria, Musella Alessandra, Mandolesi Georgia, Guadalupi Livia, Centonze Diego, Stampanoni Bassi Mario

Abstract excerpt

The clinical course of multiple sclerosis (MS) is critically influenced by the interplay between inflammatory and neurodegenerative processes. The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265), one of the most studied single-nucleotide polymorphisms (SNPs), influences brain functioning and neurodegenerative processes in healthy individuals and in several neuropsychiatric diseases....

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Brain-Derived Neurotrophic Factor
Inflammation
Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiple Sclerosis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 35205376
DOI: 10.3390/genes13020332
PMCID: PMC8871843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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The BDNF Val66Met Polymorphism (rs6265) Modulates Inflammation and Neurodegeneration in the Early Phases of Multiple Sclerosis.PMID 35205376Read ↗

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