Article
Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor.
Human molecular genetics - 15 Nov 2007
Zivadinov Robert, Weinstock-Guttman Bianca, Benedict Ralph, Tamaño-Blanco Miriam, Hussein Sara, Abdelrahman Nadir, Durfee Jackie, Ramanathan Murali
Abstract excerpt
To investigate the association of the rs6265 (Val66Met) single nucleotide polymorphism (SNP) of brain-derived neurotrophic factor (BDNF) with brain morphometry and functional status as measured by quantitative magnetic resonance imaging (MRI) and neurocognitive testing in multiple sclerosis (MS) patients. BDNF is released by neurons and by immune cells in MS brain. The rs6265 SNP variation of BDNF causes...
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