Article
GSK3β genetic variability in patients with Multiple Sclerosis.
Neuroscience letters - 15 Jun 2011
Galimberti Daniela, Macmurray James, Scalabrini Diego, Fenoglio Chiara, De Riz Milena, Comi Cristoforo, Comings David, Cortini Francesca, Villa Chiara, Serpente Maria, Cantoni Claudia, Ridolfi Elisa, Fardipoor Ma-Hin, Leone Maurizio, Monaco Francesco, Bresolin Nereo, Scarpini Elio
Abstract excerpt
Glycogen synthase kinase-3 beta (GSK3β) is a ubiquitous kinase that is part of multiple signaling pathways. It has neurotrophic/neuroprotective effects by mediating the actions of neurotrophic molecules in the brain, thus providing neuroprotection through modulation of energy metabolism. Notably, it has been demonstrated that GSK3β is involved in Wnt-beta-catenin signaling, which contributes to the inhibition of...
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