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Article

The BDNF-Val66Met polymorphism: implications for susceptibility to multiple sclerosis and severity of disease.

Journal of neuroimmunology - 1 Oct 2005

Lindquist S, Schott B H, Ban M, Compston D A S, Sawcer S, Sailer M

Abstract excerpt

Neurodegeneration following inflammatory injury is considered to be a pathological correlate of irreversible disability in patients with multiple sclerosis. The availability of neurotrophins could influence the probability or rate of disease progression and the time of onset. The BDNF-Val66Met-polymorphism leads to altered intracellular transport and secretion of BDNF, and is thus a logical candidate for a gene...

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Identifiers

PMID: 16046000
DOI: 10.1016/j.jneuroim.2005.06.008

Genes

BDNF

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The BDNF-Val66Met polymorphism: implications for susceptibility to multiple sclerosis and severity of disease.PMID 16046000Read ↗

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BDNF rs6265 polymorphism methylation in Multiple Sclerosis: A possible marker of disease progressionSemantic proximity Read ↗

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New Frontiers in Neurodegeneration and Regeneration Associated with Brain-Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism.Semantic proximity Read ↗

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy.Semantic proximity Read ↗

The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease.Semantic proximity Read ↗

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Influence of BDNF Genetic Polymorphisms in the Pathophysiology of Aging-related DiseasesSemantic proximity Read ↗

BDNF Val66Met polymorphism and brain volumes in multiple sclerosis.Semantic proximity Read ↗

Val66Met BDNF polymorphism is associated with Parkinson's disease cognitive impairmentSemantic proximity Read ↗

The implication of BDNF Val66Met polymorphism in progression from subjective cognitive decline to mild cognitive impairment and Alzheimer’s disease: a 9-year follow-up studySemantic proximity Read ↗

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