Article
Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding.
PloS one - 1 Jan 2011
Caputo Viviana, Sinibaldi Lorenzo, Fiorentino Alessia, Parisi Chiara, Catalanotto Caterina, Pasini Augusto, Cogoni Carlo, Pizzuti Antonio
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays an essential role in neuronal development and plasticity. MicroRNA (miRNAs) are small non-coding RNAs of about 22-nucleotides in length regulating gene expression at post-transcriptional level. In this study we explore the role of miRNAs as post-transcriptional inhibitors of BDNF and the effect of 3'UTR sequence variations on miRNAs binding...
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