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Article

The Association between Mutational Signatures and Clinical Outcomes among Patients with Early-Onset Breast Cancer.

Genes - 7 May 2024

Basmadjian Robert B, O'Sullivan Dylan E, Quan May Lynn, Lupichuk Sasha, Xu Yuan, Cheung Winson Y, Brenner Darren R

Abstract excerpt

Early-onset breast cancer (EoBC), defined by a diagnosis <40 years of age, is associated with poor prognosis. This study investigated the mutational landscape of non-metastatic EoBC and the prognostic relevance of mutational signatures using 100 tumour samples from Alberta, Canada. The MutationalPatterns package in R/Bioconductor was used to extract de novo single-base substitution (SBS) and insertion-deletion...

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Identifiers

PMID: 38790221
DOI: 10.3390/genes15050592
PMCID: PMC11121604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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