Article
Classification of breast cancer patients using somatic mutation profiles and machine learning approaches.
BMC systems biology - 26 Aug 2016
Vural Suleyman, Wang Xiaosheng, Guda Chittibabu
Abstract excerpt
BACKGROUND: The high degree of heterogeneity observed in breast cancers makes it very difficult to classify the cancer patients into distinct clinical subgroups and consequently limits the ability to devise effective therapeutic strategies. Several classification strategies based on ER/PR/HER2 expression or the expression profiles of a panel of genes have helped, but such methods often produce misleading results...
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