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The familial amyotrophic lateral sclerosis-associated A4V SOD1 mutant is not able to regulate aerobic glycolysis.

Biochimica et biophysica acta. General subjects - 1 Aug 2024

de Holanda Paranhos Luan, Magalhães Rayne Stfhany Silva, de Araújo Brasil Aline, Neto José Raphael Monteiro, Ribeiro Gabriela Delaqua, Queiroz Daniela Dias, Dos Santos Vanessa Mattos, Eleutherio Elis Cristina Araujo

Abstract excerpt

Under certain stress conditions, astrocytes operate in aerobic glycolysis, a process controlled by pyruvate dehydrogenase (PDH) inhibition through its E1 α subunit (Pda1) phosphorylation. This supplies lactate to neurons, which save glucose to obtain NADPH to, among other roles, counteract reactive oxygen species. A failure in this metabolic cooperation causes severe damage to neurons. In this work, using...

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PMID: 38788983
DOI: 10.1016/j.bbagen.2024.130634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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