Article
SOD1 mutations cause hypersensitivity to high-pressure-induced oxidative stress in Saccharomyces cerevisiae.
Biochimica et biophysica acta. General subjects - 1 Feb 2022
Funada Chisako, Tanino Nanami, Fukaya Miina, Mikajiri Yu, Nishiguchi Masayoshi, Otake Masato, Nakasuji Hiroko, Kawahito Reika, Abe Fumiyoshi
Abstract excerpt
Living organisms are subject to various mechanical stressors, such as high hydrostatic pressure. Empirical evidence shows that under high pressure, the oxidative stress response is activated in Saccharomyces cerevisiae. However, the mechanisms involved in its antioxidant systems are unclear. Here, we demonstrate that superoxide dismutase 1 (Sod1) plays a role in resisting high pressure for cell growth. Mutants...
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