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Article

The involvement of GSH in the activation of human Sod1 linked to FALS in chronologically aged yeast cells.

FEMS yeast research - 1 Aug 2013

Brasil Aline A, Belati Allan, Mannarino Sérgio C, Panek Anita D, Eleutherio Elis C A, Pereira Marcos D

Abstract excerpt

Mutations in Cu, Zn-superoxide dismutase (Sod1) have been associated with familial amyotrophic lateral sclerosis, an age-related disease. Because several studies suggest that oxidative stress plays a central role in neurodegeneration, we aimed to investigate the role of the antioxidant glutathione (GSH) in the activation of human A4V Sod1 during chronological aging. Transformation of wild-type and A4V hSod1 into...

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Identifiers

PMID: 23496883
DOI: 10.1111/1567-1364.12045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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