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Article

The effect of aging on post-translational modifications of wild-type human SOD1 and the A5V ALS mutant.

GeroScience - 1 Aug 2026

Freitas de Souza Gabriel, Magalhães Rayne Stfhany Silva, Monteiro-Neto José Raphael, Martins Michele, Follmer Cristian, Junqueira Magno, Eleutherio Elis Cristina Araujo

Abstract excerpt

Cu/Zn superoxide dismutase 1 (SOD1) is essential for maintaining neural health. Its functions include modulating metabolism, maintaining redox balance, regulating transcription, besides eliminating superoxide radicals, which are achieved through various post-translational modifications (PTMs). Consequently, unusual PTMs in SOD1 can impair its functionality and stability, leading to the accumulation of misfolded...

Read the complete abstract on PubMed

Topics

Humans
Protein Processing, Post-Translational
Superoxide Dismutase-1
Amyotrophic Lateral Sclerosis
Aging

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Oxidative Stress

Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 41108344
DOI: 10.1007/s11357-025-01934-w
PMCID: PMC13575052

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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