Article

The effect of aging on post-translational modifications of wild-type human SOD1 and the A5V ALS mutant

2025-06-02

Abstract excerpt

Cu/Zn superoxide dismutase 1 (SOD1) is essential for maintaining neural health. Its functions include modulating metabolism, maintaining redox balance, regulating transcription, besides eliminating superoxide radicals, which are achieved through various post-translational modifications (PTMs). Consequently, unusual PTMs in SOD1 can impair its functionality and stability, leading to the accumulation of misfolded SO...

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Literature Corpus work: b1f2f4fc-66e2-5fa3-b9dd-5c16ac7424d3
DOI: 10.1101/2025.06.02.657411

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