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Article

Alternative translation initiation by ribosomal leaky scanning produces multiple isoforms of the Pif1 helicase.

Nucleic acids research - 8 Jul 2024

Lama-Diaz Tomas, Blanco Miguel G

Abstract excerpt

In budding yeast, the integrity of both the nuclear and mitochondrial genomes relies on dual-targeted isoforms of the conserved Pif1 helicase, generated by alternative translation initiation (ATI) of PIF1 mRNA from two consecutive AUG codons flanking a mitochondrial targeting signal. Here, we demonstrate that ribosomal leaky scanning is the specific ATI mechanism that produces not only these, but also novel,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38783074
DOI: 10.1093/nar/gkae400
PMCID: PMC11229318

Genes

PIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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