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Article

Missplicing suppressor alleles of Arabidopsis PRE-MRNA PROCESSING FACTOR 8 increase splicing fidelity by reducing the use of novel splice sites.

Nucleic acids research - 10 Jun 2022

Cabezas-Fuster Adrián, Micol-Ponce Rosa, Fontcuberta-Cervera Sara, Ponce María Rosa

Abstract excerpt

Efficient splicing requires a balance between high-fidelity splice-site (SS) selection and speed. In Saccharomyces cerevisiae, Pre-mRNA processing factor 8 (Prp8) helps to balance precise SS selection and rapid, efficient intron excision and exon joining. argonaute1-52 (ago1-52) and incurvata13 (icu13) are hypomorphic alleles of the Arabidopsis thaliana genes ARGONAUTE1 (AGO1) and AUXIN RESISTANT6 (AXR6) that...

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PMID: 35639749
DOI: 10.1093/nar/gkac338
PMCID: PMC9177961

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