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The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression

23 May 2024

Abstract excerpt

Cross-sectional studies have demonstrated strong associations between physical frailty and depression. However, the evidence from prospective studies is limited. Here, we analyze data of 352,277 participants from UK Biobank with 12.25-year follow-up. Compared with non-frail individuals, pre-frail and frail individuals have increased risk for incident depression independent of many putative confounds. Altogether,...

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PMID: 38782943
DOI: 10.1038/s41467-024-48827-8

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