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Article

Frailty and psychiatric disorders: A bidirectional Mendelian randomization study.

Journal of affective disorders - 1 Jul 2024

Chen Jie-Hai, Lei Hang, Wan Yu-Fei, Zhu Xiao-Chun, Zeng Li-Ying, Tang Hao-Xuan, Zhao Yun-Feng, Pan Ying, Deng Yong-Qiang, Liu Ke-Xuan

Abstract excerpt

BACKGROUND: The association between frailty and psychiatric disorders has been reported in observational studies. However, it is unclear whether frailty facilitates the appearance of psychiatric disorders or vice versa. Therefore, we conducted a bidirectional Mendelian randomization (MR) study to evaluate the causality. METHODS: Independent genetic variants associated with frailty index (FI) and psychiatric...

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Identifiers

PMID: 38626809
DOI: 10.1016/j.jad.2024.04.024

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