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Integrated Early-Life Factors and Depression: A Multilevel Investigation of Brain Structural, Immunometabolic, and Genetic Mechanisms.

Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 Mar 2026

Yang Guangrui, Huang Hao, Wang Jingxuan, Shi Shuxiao, Jiang Xuanwei, Zhang Zixuan, Chen Meng, Feng Nannan, Xu Lan, Du Xihao, Zhong Victor W

Abstract excerpt

BACKGROUND: Early-life factors before age 18 years significantly influence depression risk, but their differential contributions and biological mechanisms remain understudied. METHODS: In this prospective UK Biobank study (N = 104,035), an early-life factor score (ELFS) was constructed using elastic net Cox models incorporating 15 early-life factors, including perinatal conditions, childhood adversities, physical...

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PMID: 40983146
DOI: 10.1016/j.bpsc.2025.09.010

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FOXP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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