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Article

Determinants of gastric cancer immune escape identified from non-coding immune-landscape quantitative trait loci.

Nature communications - 21 May 2024

Miliotis Christos, Ma Yuling, Katopodi Xanthi-Lida, Karagkouni Dimitra, Kanata Eleni, Mattioli Kaia, Kalavros Nikolas, Pita-Juárez Yered H, Batalini Felipe, Ramnarine Varune R, Nanda Shivani, Slack Frank J, Vlachos Ioannis S

Abstract excerpt

The landscape of non-coding mutations in cancer progression and immune evasion is largely unexplored. Here, we identify transcrptome-wide somatic and germline 3' untranslated region (3'-UTR) variants from 375 gastric cancer patients from The Cancer Genome Atlas. By performing gene expression quantitative trait loci (eQTL) and immune landscape QTL (ilQTL) analysis, we discover 3'-UTR variants with cis effects on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38773080
DOI: 10.1038/s41467-024-48436-5
PMCID: PMC11109163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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