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Article

Mendelian randomization identifies circulating miRNAs as causal mediators of gastric cancer susceptibility and survival outcomes.

Medicine - 2 Jan 2026

Lin Yejue, Luo Ming

Abstract excerpt

Gastric cancer (GC) remains a leading cause of cancer mortality, yet the causal roles of microRNAs (miRNAs) in its pathogenesis are poorly characterized. While observational studies implicate miRNAs in GC progression, confounding biases and tissue-specific limitations hinder causal inference and clinical translation. We conducted a 2-sample Mendelian randomization (MR) analysis using genetic instruments derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41496077
DOI: 10.1097/MD.0000000000046833
PMCID: PMC12778131

Genes

GC
ATAD5
ELL2
F2
GDNF
GNAL
UNC13A
XKR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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