Article
Divergent molecular pathways drive monomorphic epitheliotropic and enteropathy-associated intestinal T-cell lymphoma.
Leukemia - 1 Jan 2026
Vallois David, Missiaglia Edoardo, Veloza Luis, Fischer Anja, Cavalieri Doriane, Rattina Vimel, Bisig Bettina, Roh Vincent, Wiehle Laura, Sarkis Rita, Bachy Emmanuel, Bonnet Christophe, Bruneau Julie, Cairoli Anne, De Wind Roland, Drieux Fanny, Dubois Romain, Emile Jean-François, Fataccioli Virginie, Laribi Kamel, Ledoux-Pilon Albane, Lemonnier François, Llamas-Gutierrez Francisco, Morel Pierre, Parrens Marie, Poullot Elsa, Quintanilla-Martinez Leticia, Sandrini Jeremy, Somja Joan, Xerri Luc, Tournilhac Olivier, Gaulard Philippe, Siebert Reiner, de Leval Laurence
Abstract excerpt
Enteropathy-associated intestinal T-cell lymphoma (EATL) and monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) have distinctive clinical context, morphology, and immunophenotype. To characterize their genetic and molecular specificities, we compared 30 EATLs and 52 MEITLs by whole-exome, RNA and miRNA sequencing and DNA methylation profiling. Highly recurrent SETD2 loss-of-function alterations and...
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