Article
Remote modulation of lncRNA GCLET by risk variant at 16p13 underlying genetic susceptibility to gastric cancer.
Science advances - 1 May 2020
Du Mulong, Zheng Rui, Ma Gaoxiang, Chu Haiyan, Lu Jiafei, Li Shuwei, Xin Junyi, Tong Na, Zhang Gang, Wang Weizhi, Qiang Fulin, Gong Weida, Zhao Qinghong, Tao Guoquan, Chen Jinfei, Jia Zhifang, Jiang Jing, Jin Guangfu, Hu Zhibin, Shen Hongbing, Wang Meilin, Zhang Zhengdong
Abstract excerpt
The biological effects of susceptibility loci are rarely reported in gastric tumorigenesis. We conducted a large-scale cross-ancestry genetic study in 18,852 individuals and identified the potential causal variant rs3850997 T>G at 16p13 significantly associated with a decreased risk of gastric cancer [odds ratio (OR) = 0.87, 95% confidence interval (CI) = 0.83 to 0.91, P = 2.13 × 10-9]. This risk effect was...
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