Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish.

Cell biology and toxicology - 21 May 2024

Zhao Lin, Wang Li-Feng, Wang Yi-Chen, Liu Ao, Xiao Qian-Wen, Hu Ming-Chuan, Sun Ming-Zhu, Hao Hui-Yu, Gao Qian, Zhao Xin, Chen Dong-Yan

Abstract excerpt

Purinergic receptor P2Y11, a G protein-coupled receptor that is stimulated by extracellular ATP, has been demonstrated to be related to the chemotaxis of granulocytes, apoptosis of neutrophils, and secretion of cytokines in vitro. P2Y11 mutations were associated with narcolepsy. However, little is known about the roles of P2RY11 in the occurrence of narcolepsy and inflammatory response in vivo. In this study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokines
Share to Inflammation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macrophages

Share to Mutation

Share to Neutrophils

Share to Receptors, Purinergic P2

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 38771396
DOI: 10.1007/s10565-024-09882-5
PMCID: PMC11108927

Genes

P2RY11
HCRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish.PMID 38771396Read ↗

Common variants in P2RY11 are associated with narcolepsy.Semantic proximity Read ↗

Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation.Semantic proximity Read ↗

Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish.Semantic proximity Read ↗

P2rx4 deficiency in mice alleviates allergen-induced airway inflammation.Semantic proximity Read ↗

Overview of the P2 receptors.Semantic proximity Read ↗

[Advance in the research on P2X7 and inflammatory respiratory diseases].Semantic proximity Read ↗

A CRISPR/Cas9 vector system for neutrophil-specific gene disruption in zebrafishSemantic proximity Read ↗

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.Semantic proximity Read ↗

Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage SurvivalSemantic proximity Read ↗

Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile InflammationSemantic proximity Read ↗

Deletion of <i>cftr</i> leads to an excessive neutrophilic response and defective tissue repair in a zebrafish model of sterile inflammationSemantic proximity Read ↗

P2Y11 Receptors: Properties, Distribution and Functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.