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Article

Deletion of <i>cftr</i> leads to an excessive neutrophilic response and defective tissue repair in a zebrafish model of sterile inflammation

2019-11-14

Abstract excerpt

Inflammation-related progressive lung destruction is the leading causes of premature death in cystic fibrosis (CF), a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. However, therapeutic targeting of inflammation has been hampered by a lack of understanding of the links between a dysfunctional CFTR and the deleterious innate immune response in CF. Herein...

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Literature Corpus work
416dfc47-a5b6-5206-8c09-82375093c368
DOI
10.1101/842195
Open publication

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Deletion of <i>cftr</i> leads to an excessive neutrophilic response and defective tissue repair in a zebrafish model of sterile inflammationDOI 10.1101/842195
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