Article
Overview of the P2 receptors.
Seminars in thrombosis and hemostasis - 1 Apr 2005
Boeynaems Jean-Marie, Communi Didier, Gonzalez Nathalie Suarez, Robaye Bernard
Abstract excerpt
The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet dense granules), or efflux through membrane channels. In addition, recent evidence suggests that vesicular trafficking is an important pathway of nucleotide release. Once in the extracellular fluids, they are rapidly degraded by ectonucleotidases, such as CD39, that play a key role...
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