Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation

Abstract excerpt

Inflammation-related progressive lung destruction is the leading causes of premature death in cystic fibrosis (CF), a genetic disorder caused by a defective cystic fibrosis transmembrane conductance regulator (CFTR). However, therapeutic targeting of inflammation has been hampered by a lack of understanding of the links between a dysfunctional CFTR and the deleterious innate immune response in CF. Herein, we used...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neonatal Respiratory Health Research
• Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Share to Zebrafish Biomedical Research Applications