Article
Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation.
Disease models & mechanisms - 19 Dec 2017
van der Vaart M, Svoboda O, Weijts B G, Espín-Palazón R, Sapp V, Pietri T, Bagnat M, Muotri A R, Traver D
Abstract excerpt
Mutations in MECP2 cause Rett syndrome, a severe neurological disorder with autism-like features. Duplication of MECP2 also causes severe neuropathology. Both diseases display immunological abnormalities that suggest a role for MECP2 in controlling immune and inflammatory responses. Here, we used mecp2-null zebrafish to study the potential function of Mecp2 as an immunological regulator. Mecp2 deficiency resulted...
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