The structure of an ancient genotype-phenotype map shaped the functional evolution of a protein family.

Abstract excerpt

Mutations are more likely to produce some phenotypes than others, but the causal role of these production propensities in the evolution of phenotypic diversity remains unclear. There are two major challenges: it is difficult to separate the effect of the genotype-phenotype (GP) map from that of natural selection when analysing natural diversity, and most extant phenotypes evolved long ago in species whose GP maps...

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