Article

Structural basis of Omicron neutralization by affinity-matured public antibodies

2022-01-04

Abstract excerpt

The SARS-CoV-2 Omicron 1 Variant of Concern (B.1.1.529) has spread rapidly in many countries. With a spike that is highly diverged from that of the pandemic founder, it escapes most available monoclonal antibody therapeutics 2,3 and erodes vaccine protection 4 . A public class of IGHV3-53-using SARS-CoV-2 neutralizing antibodies 5,6 typically fails to neutralize variants carrying mutations in the receptor-bind...

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Literature Corpus work: 672c7b1a-d499-54e3-b00b-175d6e80e1dc
DOI: 10.1101/2022.01.03.474825

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