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Article

The Clostridium difficile spo0A gene is a persistence and transmission factor.

Infection and immunity - 1 Aug 2012

Deakin Laura J, Clare Simon, Fagan Robert P, Dawson Lisa F, Pickard Derek J, West Michael R, Wren Brendan W, Fairweather Neil F, Dougan Gordon, Lawley Trevor D

Abstract excerpt

Clostridium difficile is a major cause of chronic antibiotic-associated diarrhea and a significant health care-associated pathogen that forms highly resistant and infectious spores. Spo0A is a highly conserved transcriptional regulator that plays a key role in initiating sporulation in Bacillus and Clostridium species. Here, we use a murine model to study the role of the C. difficile spo0A gene during infection...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Bacterial

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Source

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Identifiers

PMID: 22615253
DOI: 10.1128/IAI.00147-12
PMCID: PMC3434595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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