Time-resolved analysis of Bacillus subtilis DB104 Spo0A-mutant transcriptome profile and enhancement of recombinant protein release.

Abstract excerpt

Spo0A, the master regulator of sporulation initiation in Bacillus subtilis, controls over 500 genes directly or indirectly in early sporulation stages. Although the effects of Spo0A disruption on sporulation have been extensively studied, a comprehensive understanding of the genomic response throughout growth phases remain elusive. Here, we examined the transcriptomic changes in Spo0A mutant strain, R211E, and...

Topics

• Bacillus subtilis
• Bacterial Proteins
• Gene Expression Regulation, Bacterial
• Transcriptome
• Spores, Bacterial
• Recombinant Proteins