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Article

Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2017

Chao Kinlin L, Kulakova Liudmila, Herzberg Osnat

Abstract excerpt

The exact function of human gasdermin-B (GSDMB), which regulates differentiation and growth of epithelial cells, is yet to be elucidated. In human epidermal growth factor receptor 2 (HER2)-positive breast cancer, GSDMB gene amplification and protein overexpression indicate a poor response to HER2-targeted therapy. Genome-wide association studies revealed a correlation between GSDMB SNPs and an increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28154144
DOI: 10.1073/pnas.1616783114
PMCID: PMC5321033

Genes

GSDMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.PMID 28154144Read ↗

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The Asthma Risk Gene, GSDMB, Promotes Mitochondrial DNA-induced ISGs ExpressionSemantic proximity Read ↗

Differential Expression and Copy Number Variation of Gasdermin (GSDM) Family Members, Pore-Forming Proteins in Pyroptosis, in Normal and Malignant Serous Ovarian Tissue.Semantic proximity Read ↗

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