Article
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.
PLoS pathogens - 1 Jan 2018
Ruiz-Moreno Juan S, Hamann Lutz, Shah Javeed A, Verbon Annelies, Mockenhaupt Frank P, Puzianowska-Kuznicka Monika, Naujoks Jan, Sander Leif E, Witzenrath Martin, Cambier John C, Suttorp Norbert, Schumann Ralf R, Jin Lei, Hawn Thomas R, Opitz Bastian
Abstract excerpt
The cyclic GMP-AMP synthase (cGAS)-STING pathway is central for innate immune sensing of various bacterial, viral and protozoal infections. Recent studies identified the common HAQ and R232H alleles of TMEM173/STING, but the functional consequences of these variants for primary infections are unknown. Here we demonstrate that cGAS- and STING-deficient murine macrophages as well as human cells of individuals...
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