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Article

Genetic risk of alcohol-related liver cirrhosis: Associations of PNPLA3, TM6SF2, and a two-variant polygenic risk score.

Biomolecules & biomedicine - 12 Dec 2025

Nesic Branka, Jelovac Marina, Karan-Djurasevic Teodora, Vrinic Kalem Dusica, Svorcan Petar, Zukic Branka, Grubisa Ivana

Abstract excerpt

A minority of individuals who consume excessive alcohol develop cirrhosis. Variants in the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) and the transmembrane 6 superfamily member 2 gene (TM6SF2) have been previously identified as associated with alcohol-related cirrhosis (ALC). This study aimed to examine the variants of PNPLA3 and TM6SF2 and to develop and assess a polygenic risk score...

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Source

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Identifiers

PMID: 41384813
DOI: 10.17305/bb.2025.13261
PMCID: PMC12873739

Genes

PNPLA3
TM6SF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Genetic risk of alcohol-related liver cirrhosis: Associations of PNPLA3, TM6SF2, and a two-variant polygenic risk score.PMID 41384813Read ↗

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