Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis.

Abstract excerpt

This study examined whether coffee consumption is causally associated with osteoarthritis. A two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) and weighted median estimates, and the MR-Egger regression method were performed. The publicly available summary statistical datasets of coffee consumption genome-wide association studies (GWASs) meta-analyses on coffee intake from...

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• Cell Adhesion Molecules
• Coffee
• Cytochrome P-450 CYP1A1
• Cytochrome P-450 Enzyme System
• Mendelian Randomization Analysis