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Article

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

11 Nov 2010

Abstract excerpt

PNPLA3 (adiponutrin, calcium-independent phospholipase A(2) epsilon [iPLA(2)ε]) is an adipose-enriched, nutritionally regulated protein that belongs to the patatin-like phospholipase domain containing (PNPLA) family of lipid metabolizing proteins. Genetic variations in the human PNPLA3 gene (i.e., the rs738409 I148M allele) has been strongly and repeatedly associated with fatty liver disease. Although human...

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PMID: 21068004
DOI: 10.1194/jlr.m011205

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndromePMID 21068004Read ↗

Patatin-like phospholipase domain–containing protein 3 promotes transfer of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets.Semantic proximity Read ↗

Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.Semantic proximity Read ↗

Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challengesSemantic proximity Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

Weight loss allows the dissection of the interaction between abdominal fat and PNPLA3 (adiponutrin) in the liver damage of obese childrenSemantic proximity Read ↗

Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated LipogenesisSemantic proximity Read ↗

The PNPLA3 variant I148M reveals protective effects toward hepatocellular carcinoma in mice via restoration of omega-3 polyunsaturated fats.Semantic proximity Read ↗

Experimental Models to Investigate PNPLA3 in Liver Steatosis.Semantic proximity Read ↗

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.Semantic proximity Read ↗

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.Semantic proximity Read ↗

PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans.Semantic proximity Read ↗

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation.Semantic proximity Read ↗

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