Article

Loss of adipocyte phospholipase gene <i>PLAAT3</i> causes lipodystrophy and insulin resistance due to inactivated arachidonic acid-mediated PPAR <i>γ</i> signaling

2021-04-15

Abstract excerpt

<h4>Summary</h4> PLAAT3 is a phospholipid modifying enzyme predominantly expressed in white adipose tissue (WAT). It is a candidate drug target as Plaat3 deficiency in mice protects against picornavirus infection and diet-induced obesity. We identified four patients with homozygous loss-of-function mutations in PLAAT3 , presenting with partial lipodystrophy, severe insulin resistance and dyslipidemia. PLAAT3-def...

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Literature Corpus work: 76a39a42-b35f-5c5d-b1f0-c71062b4e146
DOI: 10.1101/2021.04.15.439941

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