Article
Double mutation of claudin-1 and claudin-3 causes alopecia in infant mice.
Annals of the New York Academy of Sciences - 1 May 2023
Suzuki Koya, Yamaga Kosuke, Tokumasu Reitaro, Katsuno Tatsuya, Tanaka Hiroo, Chiba Shuhei, Yagi Takeshi, Katayama Ichiro, Tamura Atsushi, Murota Hiroyuki, Tsukita Sachiko
Abstract excerpt
Hair follicles (HFs) undergo cyclic phases of growth, regression, and rest in association with hair shafts to maintain the hair coat. Nonsense mutations in the tight junction protein claudin (CLDN)-1 cause hair loss in humans. Therefore, we evaluated the roles of CLDNs in hair retention. Among the 27 CLDN family members, CLDN1, CLDN3, CLDN4, CLDN6, and CLDN7 were expressed in the inner bulge layer, isthmus, and...
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