Article
Claudin-1 is a p63 target gene with a crucial role in epithelial development.
PloS one - 23 Jul 2008
Lopardo Teresa, Lo Iacono Nadia, Marinari Barbara, Giustizieri Maria L, Cyr Daniel G, Merlo Giorgio, Crosti Francesca, Costanzo Antonio, Guerrini Luisa
Abstract excerpt
The epidermis of the skin is a self-renewing, stratified epithelium that functions as the interface between the human body and the outer environment, and acts as a barrier to water loss. Components of intercellular junctions, such as Claudins, are critical to maintain tissue integrity and water retention. p63 is a transcription factor essential for proliferation of stem cells and for stratification in epithelia,...
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