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Article

Clinical validation of C12FDG as a marker associated with senescence and osteoarthritic phenotypes.

Aging cell - 1 May 2024

Hambright William S, Duke Victoria R, Goff Adam D, Goff Alex W, Minas Lucas T, Kloser Heidi, Gao Xueqin, Huard Charles, Guo Ping, Lu Aiping, Mitchell John, Mullen Michael, Su Charles, Tchkonia Tamara, Espindola Netto Jair M, Robbins Paul D, Niedernhofer Laura J, Kirkland James L, Bahney Chelsea S, Philippon Marc, Huard Johnny

Abstract excerpt

Chronic conditions associated with aging have proven difficult to prevent or treat. Senescence is a cell fate defined by loss of proliferative capacity and the development of a pro-inflammatory senescence-associated secretory phenotype comprised of cytokines/chemokines, proteases, and other factors that promotes age-related diseases. Specifically, an increase in senescent peripheral blood mononuclear cells...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 38708778
DOI: 10.1111/acel.14113
PMCID: PMC11113632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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