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Single-cell fluorescence imaging reveals heterogeneity in senescence biomarkers and identifies rapamycin-responsive sub-populations

2024-11-21

Abstract excerpt

Cellular senescence is a state of irreversible cell cycle arrest accompanied by a distinctive inflammatory secretory profile known as the senescence-associated secretory phenotype (SASP). While various biomarkers, such as senescence-associated beta-galactosidase (SA-βgal), EdU incorporation, P21, and P16, are used to identify senescent cells, no single biomarker universally defines cellular senescence, and current...

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Literature Corpus work
eba8847f-6c6c-58c3-b293-289eaa16e340
DOI
10.1101/2024.11.21.624614
Open publication

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Single-cell fluorescence imaging reveals heterogeneity in senescence biomarkers and identifies rapamycin-responsive sub-populationsDOI 10.1101/2024.11.21.624614
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